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Critical Appraisal of the Meta-Analysis One observation of concern is that whereas heterogeneity was low in most of the analyses, it was very high for the short-term ( 8 weeks) PANSS-N and PANSS-Total analyses ( I 2 = 89% and 90%, respectively) in both of which only the RCTs from Iran 7 and China found a statistically significant advantage for NAC vs placebo