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Description

Takada, M., Fujimoto, M., Yamazaki, K., Takamoto, M., & Hosomi, K

It protects the cancerous cells by conferring resistance to chemotherapeutic drugs

10.3390/molecules26010085

It has been shown that deletion of T Cell Receptor Alpha Constant (TRAC), B2M, and PDCD1 in universal EGFRvIII and CD19-CAR-T cells enhanced their anti-tumor responses, respectively, against both solid and hematologic malignancies (glioblastoma and leukemia)