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Hepatology (Baltimore, Md)

This metabolic roadblock explains why patients with ME/CFS and Long COVID experience such profound, unyielding fatigue

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Studies examining long-term L-citrulline use have demonstrated that supplementation may reduce systolic blood pressure and can reduce diastolic blood pressure at doses greater than or equal to six grams per day.8 Acute use of similar doses has also resulted in positive effects.9 For those at risk of heart disease and hypertension, supplementing citrulline may help prevent the need for medications down the line, though this is a sensitive enough area of your health that you should definitely speak with your doctor before taking it