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Glutathione production by our bodies naturally decreases with age, but can also be impacted by diet, physical activity, alcohol intake, infections, stress, certain medications, and chronic illness

To move beyond descriptive pathway enrichment and identify mechanistically relevant signaling programs, a focused gene set enrichment analysis (GSEA) was performed, emphasizing pathways associated with oxidative stress and innate immune activation

3.1 Mitochondria-associated metabolic reprogramming of macrophages Mitochondria serve as the central hub for macrophage metabolic plasticity, which plays an important role in energy production, immune regulation, signal transduction, and cell fate determination, intervening the inflammation regulation and macrophage repair (84)

Le glutathion stimule galement le mtabolisme nergtique des lymphocytes T : au-del de ses pouvoirs antioxydants, le gluthation se rvle tre un commutateur molculaire cl pour le systme immunitaire : en effet, la molcule stimule galement le mtabolisme nergtique des lymphocytes T et les aide crotre, se diviser et combattre les virus