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Novel synthetic derivatives demonstrate increased half-life and reduced susceptibility to oxidation compared to natural EGCG

Tsuda M, Kaga A, Anai T, Shimizu T, Sayama T, Takagi K, Machita K, Watanabe S, Nishimura M, Yamada N, Mori S, Sasaki H, Kanamori H, Katayose Y, Ishimoto M (2015) Construction of a high-density mutant library in soybean and development of a mutant retrieval method using amplicon sequencing

The tide began to turn in 1988 when research revealed that TNF- could trigger both apoptotic and necrotic cell death, suggesting that necrosis may not be a mere accident but a controlled process

This review summarises the role and mechanisms of mitochondrial dysfunction in RA and discusses the potential and challenges of mitochondria as a novel therapeutic strategy for RA, highlighting the potential of mitochondria as a promising breakthrough point for the prevention and treatment of RA