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PHMB@Au NPs exhibit superior synergistic effect to enhance both photothermal bactericidal effect under NIR irradiation and tissue repair by converting macrophages from M1 type to M2 type ( Table 3

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Disclosures: Liam Swain: Nothing to Disclose, Abdel Shaheen: Nothing to Disclose, Meng Wang: Nothing to Disclose, Jennifer Flemming: Nothing to Disclose, Mayur Brahmania: Nothing to Disclose, Juan Abraldes: Gilead: Grant/Research Support, 89bio: Consultant, Boston Pharmaceuticals: Consultant, Novo Nordisk: Consultant, Boehringer Ingelheim: Consultant, Astra Zeneca: Consultant, Agomab: Consultant, Terumo: Speaking and Teaching, Cook: Grant/Research Support, Karen Tang: Nothing to Disclose, Jenny Godley: Nothing to Disclose 1550 ENGINEERED HUMAN LIVER CO-CULTURES TO MODEL HEPATIC DYSFUNCTIONS IN METALD Owen Lally 1 , 1 University of Illinois Chicago Background: Metabolic dysfunction-associated liver disease (MASLD) with increased alcohol intake is characterized by symptoms of both MASLD and alcohol-associated liver disease (ALD), known as MetALD

These effects were observed across multiple organ systems and disease models, highlighting its broad therapeutic potential