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Signs and Symptoms of an Overdose Respiratory depression: slow and shallow breathing or cessation of breathing Snoring, choking, or gurgling sounds Tiny pinpoint pupils Limp body Unable to talk Disorientation Pale, gray, or bluish skin, lips, or nails Cold or clammy skin Decreased level of awareness or consciousness Extremely sleepy or passing out If you suspect an overdose, call 911 immediately and administer Narcan if its available

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Thus, we conclude that moderate-mutant tumor cells are the primary drivers of enhanced tumor growth