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Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets

Unusual Compound with Fluorine Atoms : In cases where you encounter a compound with highly electronegative atoms like fluorine near the acidic hydrogen, make a conservative estimate