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4) Impaired Kidney Function Chronic kidney disease patients had higher TMAO levels compared to controls in a study with 521 patients and 3,166 controls

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Trop J Pharm Res 21:17471753

NAD + also plays an important role in DNA repair, serving as a substrate for poly-(ADP-ribose) polymerase (PARP) enzymes that are involved in the response to DNA damage (127130)