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Data availability All data are available upon request from the authors and summary data will be made available via the UK Biobank ( Funding This work was supported by Health Data Research UK, an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations and leading medical research charities

inspect for discolouration or particles (note that B12 solution is normally red) Prepare the injection site common sites include the thigh (vastus lateralis) for both IM and SC injections, or the ventrogluteal area for IM administration if trained to use this site Administration technique: Clean the injection site with an alcohol wipe and allow to dry completely