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In fact, due to its microenvironment dependence, tryptophan is an excellent intrinsic probe for the analysis of conformational changes of proteins upon binding of ligands 38

Now, this does not take into account the dioxins, the PCBs, and the other contaminants that may tip the scale away from eating fish

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This was accompanied by a significant increase in Nrf2 activity and HO-1 expression, and the effects observed were more potent than hemin (106), a synthetic mimic of heme which is not suitable for clinical use