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CM-272 inhibits G9a, DNMT1, DNMT3A, and DNMT3B with an IC 50 of 8 nM, 382 nM, 85 nM, and 1,200 nM, respectively (Figure 8), and promotes the apoptosis of various tumor cells in vitro

Access this article Similar content being viewed by others Abbreviations AMPA: Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid CNS: Central nervous system DC: Dendritic cell EAE: Experimental autoimmune encephalomyelitis GluR: Glutamate receptors iGluRs: Ionotropic glutamate receptors Kainate: 2-carboxy-3-carboxymethyl-4-isopropenylpyrrolidine mGluRs: Metabotropic glutamate receptors MS: Multiple Sclerosis NMDA: N-methyl-d-aspartate Teff: Effector T cell Treg: Regulatory T cell Th: Helper T cell References Affaticati P, Mignen O, Jambou F, Potier MC, Klingel-Schmitt I, Degrouard J, Peineau S, Gouadon E, Collingridge GL, Liblau R, Capiod T, Cohen-Kaminsky S (2011) Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

211At-Labeled nanoscale polydopamine decorated with FAPI for synergistic targeted-alpha therapy and photothermal therapy of glioma

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