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Table 1 summarizes the various studies carried out to evaluate the effects of polyphenol in reversing MDR in cancer cell lines

Colloids Surf B: Biointerfaces 115:125131 Tsao J-Y, Wu C-P, Tsai H-H, Peng K-C, Lin P-Y, Shan-Yu S, Chen L-D, Tsai F-J, Tsai Y (2012) Effect of hydroxypropyl--cyclodextrin complexation on the aqueous solubility, structure, thermal stability, antioxidant activity, and tyrosinase inhibition of paeonol

These actions may be associated with the suppression of the signal transducer and activator of transcription 3/Notch signaling axis, downregulation of the anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), and upregulation of P53 expression

Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats