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It greatly improves the solubility and stability of drug-loaded micelles

ovulation) stimulates the production of the ROS (122)

Free radicals mediate the mitochondrial membrane depolarization and release of cytochrome C which in turn activate and induce the apoptosis process.114,115 A single study has reported the protective role of melatonin against vancomycin-induced nephrotoxicity in comparison with other important antioxidants.116 Intraperitoneal administration of vancomycin 10mg/kg, for 7 days, severely enhanced the serum creatinine, urea and malondialdehyde (MDA) levels which indicated the impaired renal function and cellular injury