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The latter derives from the cleavage of POMC by prohormone convertase-1 and acts via melanocortin-3 and -4 receptors (MC3R, MC4R) activation

Acknowledgements This work was supported by the Shin Nippon Biomedical Laboratories Ltd., the Smoking Research Foundation, and a Grant-in-Aid for Early-Career Scientists from the Japan Society for the Promotion of Science (No

Initial treatment for B12 deficiency with neurological involvement: When elderly patients present with neurological symptoms (peripheral neuropathy, cognitive impairment, subacute combined degeneration of the cord), urgent and aggressive replacement is essential to prevent irreversible damage