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Acute gallbladder disease events, such as cholecystitis or cholelithiasis, have been reported in clinical studies

These studies used doses ranging from 1 mg per day to 30 mg per day administered through various routes (subcutaneous, oral, and intranasal)

The exact cause of vitiligo, where pigment-producing cells (melanocytes) die or stop producing melanin, remains unclear

In all of these studies, TPh reduced cellular influx into the airways, eosinophilia, and decreased the levels of pro-inflammatory cytokines such as IL-1, 4, 5, and 13, along with decreasing the levels of the IgE and NO metabolites in the lungs [383,384,401,402,403,404]