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The top spotted metabolic pathways were glycine, serine, and threonine metabolism, alanine, aspartate, and glutamate metabolism, taurine and hypotaurine metabolism, sphingolipid metabolism, arginine and proline metabolism, glutathione metabolism, glyoxylate and dicarboxylate metabolism, aminoacyl-tRNA biosynthesis and biotin metabolism, and beta-alanine metabolism (Wang et al., 2021)

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