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demonstrated that the expression of IL-6 in epidermal MCs was significantly increased following stimulation with H 2 O 2 , suggesting that oxidative stress may induce IL-6 expression and exacerbate the inflammatory response of epidermal MCs in patients with vitiligo [68]

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Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19