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DTNB modification of SH groups of isocitrate dehydrogenase from Bacillus stearothermophilus purified by affinity chromatography

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We demonstrated the presence of eNAPRT in sera from patients with a diagnosis of cancer, including solid tumors (prostate, lung and bladder cancer, mesothelioma and metastatic melanoma) and hematological malignancies [myeloma, chronic lymphocytic leukemia (CLL), and diffuse large cell lymphoma (DLCL)] (124) as summarized in Table 1