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From the present review, it is evident that small peptides exert towards oral cells and tissues an antitumor activity through apoptosis or selective necrosis of cell lines specifically associated with oral squamous cell carcinoma, an antimicrobial function by maintaining the balance of the oral microbiome, an immunomodulatory function through up and down-regulation of important genes involved in immunoregulatory gene cascades, and finally a cell differentiation function towards major stem cells in the oral cavity, even in absence of growth factors [21, 27,28,29,30,31, 34, 35]

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Taken together, these findings suggest that GMSC-derived Schwann-like cells retained potent capabilities to promote pro-regenerative (M2) macrophage polarization while suppressing pro-inflammatory (M1) macrophage activation in crush-injured sciatic nerves of rats

This growing global distribution highlights the urgent need for early detection, preventive screening, and integrative approaches that address both disease management and long-term quality of life [3][2]