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Elsevier Health Sciences Hertog MG, Hollman PC, Katan MB, Kromhout D (2009) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands

doi:10.1016/j.ejpn.2019.06.002

The standard dose escalation schedule reflects this predictability: At each dose, four weeks allows the drug to reach steady state at that level before judging efficacy

The inflammasome within macrophages exacerbates the advancement of AD, while the absence of NLRP3 mitigates oxidative stress and regulates macrophage polarization