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In this study, using natural polysaccharides, such as guar gum and chitosan, as carriers and diltiazem hydrochloride as the model medication, a novel colon-targeted tablet formulation was created

In general, dosing for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy

[16] Less common but clinically important reactions comprise venous thrombosis, fluid overload, and acid-base disturbances