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As an additional test of the specificity of the effect, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate ( SI Appendix , Fig

It is, therefore, possible that redox thresholds in B cells are subset-specific, and that these thresholds mediate homeostatic functions that could account for the differing properties of MZB and FoB

then studied the effects of mitochondrial ROS on T cell function and expansion

As you get older, your body naturally produces less of this essential coenzyme, which fuels your mitochondria - the energy centers of every cell