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PMC 4453489

The most common causes include: Inadequate dietary intake (common in vegetarians/vegans) Malabsorption syndromes (e.g., celiac or Crohns disease) Atrophic gastritis Long-term use of acid-reducing medications Pernicious anemia (an autoimmune condition) B12 deficiency is one of the leading reversible causes of anemia

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Since computer simulations are highly dependent on previous experimental data, and the pathways and mechanisms of NPs toxic effects have not been fully elucidated, computer models may not be able to predict the toxic effects of NPs accurately