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Strikingly, our GSEA analysis also showed that ablation of Gclc in FoB displayed a similar increase in mTORC1 signaling genes compared to Gclc fl/fl FoB and Gclc fl/fl MZB (Fig

A central event is the degradation of E-cadherin, a key adherens junction protein, resulting in loss of barrier cohesion and increased permeability (90)