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Proteomic identification of 14-3-3zeta as an adapter for IGF-1 and AKT/GSK-3beta signaling and survival of renal mesangial cells

Zhu C, Yuan T, Krishnan J

Disruption of this regulatory circuit, as observed in PD patients with lower heart rate variability (a sign of vagal dysfunction), causes exacerbated systemic inflammation and greater microglial priming once peripheral cytokines or endotoxins reach the CNS [121]