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PubMed Robertson L, Lee AJ, Evans CJ, et al

Recently, exhaustion of GSH in cisplatin-resistant cells has been extensively utilized to strengthen the cytotoxicity of cisplatin and sensitize chemotherapy ( Platinum precursors such as Pt () are applied to produce Pt () as a GSH-scavenging agent

Reconstitution math below is built around this vial

In cancer cells, cysteine deficiency blocks GSH synthesis and, consequently, the activity of GPX4 and its capacity to suppress ferroptosis is impaired