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Serum cytokine levels were elevated in untreated breast cancer patients (Group II) and significantly reduced after tamoxifen therapy for more than 1 year (Group III)

10.1146/annurev-biophys-101920-082204 [DOI] [PMC free article] [PubMed] [Google Scholar] 10

In contrast, under oxidative stress NRF2 dissociates from KEAP1 and translocates to the nucleus, where it activates the downstream expression of antioxidative response element (ARE)-containing target genes, many of which have been shown to play a role in defending against ferroptosis [65, 66]