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Description

25 ) and CC6.33 (ref

Of note, unlike carbonyl scavengers that target only a single line of defense, NRF2 regulates genes across all three defense lines, including those encoding antioxidant enzymes, RLA-detoxifying enzymes, and components of the 20S proteasome and lysosome, such as Proteasome Subunit -Type 5 (PSMB5), PA28, and Sequestosome-1 (p62) (216223)