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May be a marker of underlying disease (e.g., liver disease, malignancy, MDS/CML)

This serine/threonine (S/T) kinase is constitutively active, with widespread functions beyond Wnt signaling 3 , but its association with the Axin scaffold protein directs its enzymatic activity towards -catenin 4 , to route this Wnt-specific substrate for ubiquitylation and proteasomal degradation 5

Amylin agonists feel more like a portion governor, a sense that the meal is genuinely finished even when habit says keep eating