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KPV inhibits NF-B signaling to suppress pro-inflammatory cytokine production while supporting gut barrier function, reducing systemic inflammation and promoting mucosal healing

However, ADH is considerably more sensitive to small changes in osmolality than changes in blood volume: a 1% decrease of plasma osmolality stimulates ADH secretion, whereas a 10% decrease in blood volume is necessary to clearly increase ADH levels ( Guyton and Hall 2006 )