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Mechanisms of action include modulation of resident microbes, enhancement of epithelial barrier functions, modulation of local and systemic immune responses, modulation of systemic metabolic responses, and systemic signaling via the nervous system (72, 76)

NF-B: nuclear factor kappa-light-chain-enhancer of activated B cells When the coronary arterys blood supply is blocked, MI happens [78]

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Based mainly on in vitro and animal studies, polyphenol metabolites may exert several beneficial effects in the gut: (1) they selectively encourage the growth of beneficial bacteria (i.e., have a prebiotic effect)