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Description

The GSH-responsive degradation of KBiF 4 @HSA Recently, studies have demonstrated that GSH concentrations in tumor tissue are 1001000 times higher than those in blood and normal tissues, with notable intracellular GSH concentrations in tumor cells ranging from 1 to 15 mM [49]

Critically, we identified that the majority of SUMOylated proteins deregulated in CCA were involved in cell proliferation, survival or cell homeostasis

In such a model, multiple binding motifs on the same receptor, each with weak intrinsic affinity, would act in concert to increase the effective receptor protein concentration and thus support high-affinity binding to multimerized LC3/GABARAPs (Llus Garcs et al, 2009