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Common signs include: Ongoing fatigue or weakness Pale skin Numbness or tingling in the hands and feet Brain fog, forgetfulness, or trouble concentrating Low mood, anxiety, or irritability Poor appetite or digestive upset When B12 is low, your metabolism slows, you have less energy for activity, and appetite signals can get thrown off, all of which make weight loss harder

Arch Intern Med 166(18):19751979 Campbell JM et al (2018) Metformin use associated with reduced risk of dementia in patients with diabetes: a systematic review and meta-analysis

Medical Re-Evaluation Week 5 Zoom call to inquire Diagnostic assessment In this study, all patients were examined by an independent physician prior to entering the study