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furthermore, preeclamptic dams injected with these regenerated extensive placental vascularity ( In a different investigation, it was shown that EXOs miR-139-5p from HUCMSCs-EXOs accelerated trophoblast invasion and migration, activated the ERK/MMP-2 pathway, and blocked trophoblast apoptosis by decreasing protein tyrosine phosphatase expression, all of which improved PE manifestations in rats (Liu et al., 2020b)

Exposure to p28 increased the level of Pirh2, possibly as a result of significant post-translational increase in p53 and TAp73 in this cell line (Figure 7)

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