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Skin penetration, plasma binding, and copper-pool dynamics complicate dose extrapolation

This aligns with the understanding that B12, as a key player in one-carbon metabolism, can influence ovarian response and embryonic development [9]

In certain embodiments, the subject may be a subject having a baseline intracellular level of GSH, tGSH, or both, when compared to children without a diagnosis of autism (it has previously been found that plasma, intracellular, and even brain levels of GSH may be decreased compared to control children without autism