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All procedures were approved by the Ethics Committee on Experimental Animals of the Federal University of Par (under number 7599261120), following the Guide for the Care and Use of Laboratory Animals recommendations (National Research Council US, 2011) and the ARRIVE guidelines (du Sert et al., 2020)

The proposed DC Function measure would also follow a calculation approach similar to the existing functional outcome measures, which are CBE endorsed, with some modifications

Superoxide dismutase (SOD) as antioxidant SOD catalyses the dismutation of O 2 - to O 2 and H 2 O 2 (which is less reactive) (McCord and Fridovich 1969)

System Xc is ubiquitously expressed in the brain, involving the bloodbrain barrier and the entire brain parenchyma (Lewerenz and Maher 2011)