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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)

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In contrast, NF-B can inhibit Nrf2 activity by enhancing the recruitment of histone deacetylase 3 (HDAC3) to the ARE region, thereby preventing the transcription of ARE genes (Wakabayashi et al., 2010)

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