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At both exponential and stationary phases, we also did not observe any difference in growth among the assayed strains, supporting the conclusion that PmtA is not regulated by heavy metals

Among the many signaling pathways associated with UC, abnormal activation of the PI3K/Akt signaling pathway may be one of the important mechanisms in the pathogenesis of UC, which has attracted attention for its multiple roles in regulating inflammatory responses, reducing oxidative stress, modulating apoptosis and autophagy, repairing the intestinal mucosal barrier, and maintaining the balance of gut microbiota (Figure 1)

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