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10.1016/j.freeradbiomed.2017.03.011 86 LiY.ChenL.ZhengD.LiuJ

Patient 2 is a 35-year-old female with focal unaware seizures from right hemisphere with whole-cerebral spread status post long-term vagal nerve stimulator placement in 2013 (6 years prior to the current study) and no prior surgical intervention, currently on lamotrigine, carbamazepine, and topiramate

The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]