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Other studies show that calcium oxide crystals induce mitochondrial dysfunction in macrophages.[ref][ref] High dietary oxalate intake causes some, but not all, people to have statistically significant decreases in mitochondrial metabolic function.[ref] Animal models of high oxalate levels show that there is an increase in mitochondrial reactive oxygen species (ROS) that can lead to oxidative stress if glutathione is inadequate

Doctors and researchers are already jokingly referring to retatrutide as the "King Kong" for weight loss because early results in clinical trials suggest it rivals bariatric surgery, and it seems to protect more lean muscle mass

Apart from the cosmetic angle, many also report improved energy levels, reduced inflammation, and better immune function over time