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A major complication of blood transfusion is hemolytic transfusion reactions that occur primarily in RBC alloimmunized patients and SCD patients, in particular, are at high risk because of the mismatch in donor pool (predominantly Northern European descent) while SCD patients are predominantly of African descent (Vichinsky et al., 1990

Cancer 128(16):3019-3026, 2022

Interestingly, this protein has some characteristics that are important in CC: PGC-1 is a coactivator for the transcription of other proteins that act in energy metabolism

Nutrients such as Selenium and Vitamin C also support this process by helping recycle and stabilize Glutathione