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Given that insulin use is atypical in MODY 2, the proband underwent reassessment, showing markedly low fasting C-peptide (0.08 and 0.05 ng/mL), strongly positive anti-GAD (67 IU/mL), and negative IA-2A, ZnT8A, and ICA antibodies

Exposure to toxins such as organophosphates, which are cholinesterase inhibitors, prolongs and amplifies the effects of acetylcholine (153)

153 The extracellular matrix (ECM), a non-cellular component of the tumor microenvironment, has a physical structure and chemical composition often associated with tumor progression