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I.KangS

(2009) 4:e5650

Meanwhile, many adverse reactions associated with these drugs, including hypoglycemia and gastrointestinal problems, can cause extremely painful experiences for patients ( As the advantages of traditional Chinese medicine (TCM) in chronic diseases continue to manifest, several TCMs are used in the treatment of diabetes with mild side effects (Zheng et al., 2019)

Considering that quercetin is also an effective Sirt1 activator (24,25), the present study investigated whether quercetin inhibits ferroptosis and alleviates LPS-induced ALI by activating the Sirt1/Nrf2/Gpx4 pathway