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Continued monitoring and additional studies are essential to fully understand the long-term safety and efficacy of this therapy ( In this review, we provide an up-to-date understanding of the molecular mechanisms and regulatory pathways involved in A1AT immunomodulatory actions, as well as its homeostatic functions in metal and lipid metabolism

Nanayakkara PW, Teerlink T, Stehouwer CD, Allajar D, Spijkerman A, Schalkwijk C, ter Wee PM, van Guldener C

215 With age, the reduced pool of nave T cells may impair the ability of the immune system to detect these antigens, creating what is referred to as holes in the repertoire. This limitation could reduce the effectiveness of immunotherapies targeting neoantigens

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