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Although studies with cereblon-based PROTACs are still scarce, it is expected that long-term clinical use of this type of degrader could lead to the emergence of mutations that prevent PROTAC from binding to cereblon, thus preventing poly-ubiquitination of the target protein

10.1371/journal.ppat.1004679 348 VanhaesebroeckB.StephensL.HawkinsP

Alterations in neurotransmitter levels in exposed animals were consistent with neurobehavioral effects in animals (eg, behavioral sensitization, spontaneous locomotor activity, sensorimotor gating, and auditory processing) and audiological effects identified in both humans and animals

And when they do happen, youll have a good plan in place to manage the symptoms