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With respect to age-related diseases, such as AD, and advancing age, it was indicated that the melatonin concentrations in individuals reduce, which is highly correlated with disease progression and genotype (Reiter 1992

) administered once daily for 7 or 21 days significantly reversed corticosterone-induced depressive-like behaviors

In future studies, gene knockout or overexpression approaches will be employe to functionally validate the roles of key regulatory genes in anthocyanin synthesis

The effect of Mediterranean diet instructions on depression, anxiety, stress, and anthropometric indices: a randomized, double-blind, controlled clinical trial