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suggested that an organized process of senescence in, and ultimately removal of, a subgroup of endometrial stromal cells contributes to the overall remodeling and regrowth of the endometrium during the proliferative phase ( Cellular senescence is a phenomenon described in proliferative tissue including the endometrium and can occur under physiologic conditions when a cell reaches its final telomere length or under the influence of oxidative stress and other stressors such as DNA damage, inflammation, and epigenetic modifications ( While serving a physiologic function, senescence may also be associated with pathological conditions such as neurodegeneration and atherosclerosis, cancer and immune system dysregulation