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The expanded network in period C could result from the mature livers need for stable TCA cycle flux to support its own nutrient needs and those of other tissues

Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease

The features linked to immune enhancement, cancer resistance, DNA repair and chromatin stability may help to explain the shark's extreme lifespan, said Dorota Skowronska-Krawczyk , a physiologist and biophysicist at the University of California, Irvine, who recently showed how DNA-repair-associated genes in the retina may help keep the Greenland shark's eyesight clear over its long life

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