glutathione how are they made Glutathione-Related Enzymes and Proteins: A Review 8 Ways to Boost Glutathione

Arch Intern Med 2006

CoQ10, as an electron carrier in the ETC and an endogenous lipophilic antioxidant, can reduce the expression of CoQ10 and increase its regeneration rate, thereby alleviating cystine deprivation-induced mitochondrial membrane potential hyperpolarization, lipid peroxidation, and ferroptosiss

Therefore, CHAC1 likely serves a cytoprotective role when excess GSH is detrimental to the cell, such as conditions of reductive stress 85,86

Recently, it has been illustrated that HCBP6 (FUNDC2), a mitochondrial outer membrane protein FUN14 structural domain containing 2, can interact with and destabilize SLC25A11, thereby affecting mGSH levels and regulating ferroptosis in the myocardium [61]